Abstract

Introduction

Cobb’s collar[1] or Moormann’s ring[2] is a largely underestimated cause of male bulbar urethral strictures. It can potentially lead to acute urinary retention, upper urinary tract dilatations, enuresis, infection, poor streaming, and hematuria. Embryologically, this focal bulbar urethral stricture develops due to failure of canalization of the cloacal membrane during fetal development.[3] In Cobb’s collar, the site of obstruction is more distal than that seen with posterior urethral valves (PUV).[4] A prompt diagnosis with minimally invasive treatment may avoid upper and lower tract deterioration in these patients. We present two cases of congenital bulbar urethral obstruction (Cobb’s collar) occurring in brothers. The anatomy, embryology, and clinical features are discussed in order to turn the spotlight on to this rare disease.

Case Reports

Discussion

The proximal prostatic and membranous part of the male urethra is formed by endodermal tissues and the penile part is formed from the phallic portion of the urogenital sinus. Congenital idiopathic urethral stricture may result from incomplete rupture of the cloacal membrane at the junction of membranous and bulbar urethra which may correspond to submeatal stenosis in girls.[3]

Cobb et al. (1968) were the first to draw attention to the entity of congenital stricture of the bulbar urethra.[1] They analyzed 52 cases of proximal bulbar urethral obstruction in male patients for a 3-year period. Twenty-six out of 52 patients were boys under 16 years of age; of these 26 boys, 16 had a trabeculated bladder, 15 showed a dilated prostatic fossa, whereas 6 had a secondary hydroureter, and the most frequently referred symptoms were enuresis, urinary tract infection, hematuria, and failure to thrive. Three different types of Cobb’s collar have been identified. All these forms of obstruction are located just below the external sphincter[5] [Figure 4].

Such strictures of the bulbar urethra had been underestimated for many years until the first half of the 1990s when Dewan et al.[6] and later Nonomura et al.[7] redefined and classified the bulbar urethral narrowing by reviewing video-recorded cystoscopies as well as radiological pictures in the patients. Both studies showed that the majority of patients were below 1 year of age with a large number showing vesicoureteral reflux (VUR), with no history of urethral trauma, catheterization, or instrumentation. VUR in association with clinical findings and endoscopic findings of vestigial remnants at the level of bulbar urethra indicates that this narrowing has a congenital onset. Presentation at a later age, as occurred in our cases, may represent delayed presentation of a congenital stricture. Their response to treatment is clearly different from that of the under 1 year olds, since majority require buccal mucosal onlay urethroplasty or scrotal or penile island flap urethroplasty. The more common causes of congenital urethral stricture are different types of posterior urethral obstruction, which was originally described as PUV (three types) by Young et al., but these obstructions were found to be diaphragmatic obstruction as suggested by Parkkulainen on endoscopic studies.[8] Congenital attachment of the verumontanum to the anterior wall of the posterior urethra is the embryologic forerunner to the congenital obstruction of the posterior urethra. Congenital obstructing posterior urethral membrane (COPUM), first described by Dewan et al., is a new terminology of the same. More distal bulbar urethral abnormality without folds running up to the verumontanum is likely to be a remnant of urogenital diaphragm, commonly known as Cobb’s collar.[9]

Banks et al.,[10] in their series of 12 pediatric patients with bulbar or posterior urethral stenosis, identified a sort of bimodal distribution of age at presentation, with 50% of patients presenting during the first year of life, whereas 5 of the remaining 6 patients presented after the age of 11. This late presentation may represent a delayed presentation of a congenital stricture, or may be due to a forgotten urethral trauma or asymptomatic inflammation. Clinical presentation may be variable and, often, may be related to the use of blind urethral catheterization in these patients. Chronic urinary retention and bilateral hydronephrosis may be a presenting feature in some patients, as in our case.[10,11] These adult patients may also complain of poor ejaculation.[5] Late presentation of Cobb’s collar (caused by a persistence of urogenital membrane) can be differentiated from acquired stricture by the absence of the characteristic folds between COPUM anomalies and verumontanum.[12]

Pediatric urologists continue to debate whether the Cobb’s collar or Moormann’s ring represents a true urethral stricture or not. Some consider Cobb’s collar to be a benign physiological narrowing of the bulbar urethra, easily passable with a cystoscope, although Cobb describes a series of bulbar strictures in a pediatric population in his original paper. So, although rare, Cobb’s collar has to be considered in the differential diagnosis of progressive urinary flow obstruction and enuresis, especially in pediatric and adolescent patients where acquired traumatic, iatrogenic, or inflammatory strictures are more common. Radiologically indistinguishable dysfunctional voiding due to involuntary contraction of urethral sphincter or pelvic floor muscles and Hinman syndrome (functional non-neurogenic bladder) are also important differential diagnoses to be considered. Contrast-enhanced conventional radiological studies can identify this anomaly and also be helpful in postoperative follow-up of this entity which can be easily treatable by minimally invasive endoscopic corrective surgery.[12] Late-onset cases may need urethroplasty. Familial occurrence of Cobb’s collar is exceedingly rare and only few cases are reported in the literature, indicating that this entity may have a familial basis.[13] Screening for family members is an important part of managing these patients. In the absence of traditional risk factors, careful family history should be taken. If the biopsy of the stricture and histological examination shows a normal urethral mucosa and the absence of any inflammation or fibrosis, then Cobb’s collar becomes the likely diagnosis.

Conclusion

From the limited data available and from the cases reported here, it is clear that urethral strictures often present with an unknown etiology. Although extremely uncommon, in cases of adolescent or pediatric patients presenting with symptoms of progressive urinary obstruction and enuresis with or without urinary tract infection and/or hematuria, a bulbar urethral obstruction such as Cobb’s collar should be considered.

Acknowledgment

Footnotes

References