LE y corticoides intrauretrales

Medical Management of Penile and Urethral Lichen Sclerosus with Topical Clobetasol Improves Long Term Voiding Symptoms and Quality of Life

J Urol. 2020 Jul 27;101097JU0000000000001304. doi: 10.1097/JU.0000000000001304. Online ahead of print.


Joshua P Hayden  1 , William R Boysen  2 , Andrew C Peterson  2


Purpose: We sought to evaluate the success of minimally invasive management of lichen sclerosus with topical and intraurethral clobetasol, as defined by improvement in patient reported outcome measures and non-progression to surgery.

Materials and methods: We conducted a review of our prospective ongoing quality improvement study to determine outcomes of our current standard practice for males with penile and urethral biopsy-proven lichen sclerosus. Data were collected between 2011 and 2019 and included patient demographic information, medical and surgical histories, and location and extent of lichen sclerosus-related pathology. The primary outcomes for this study were voiding function and voiding-related quality of life and were assessed using the American Urological Association Symptom Score and quality of life bother index, respectively.

Results: We identified 42 patients with biopsy-proven lichen sclerosus related urethral stricture disease. 85.7% were treated with intraurethral steroids alone and did not require surgical intervention. Median American Urologic Association Symptom Score significantly improved from 12 to 8, and median quality of life bother index improved from 4 («mostly dissatisfied») to 2 («mostly satisfied»). Average stricture length of those with penile urethral disease and bulbar urethral disease was 4.8 cm (3.0) and 16.2 cm (6.5), respectively. Median follow up was 8.4 months (IQR 2.6-26.4).

Conclusions: Lichen sclerosus-related urethral stricture disease can be effectively managed with intraurethral steroids. This minimally invasive management strategy improves patient-reported voiding symptoms and voiding quality of life.