{"id":741,"date":"2018-11-03T12:49:09","date_gmt":"2018-11-03T12:49:09","guid":{"rendered":"http:\/\/cru.aeu.es\/?p=741"},"modified":"2018-11-03T12:49:09","modified_gmt":"2018-11-03T12:49:09","slug":"esclerosis-en-la-muestra-histologica-tras-uretroplastia-pronostico","status":"publish","type":"post","link":"https:\/\/cru.aeu.es\/?p=741","title":{"rendered":"Esclerosis en la muestra histol\u00f3gica tras uretroplastia: pron\u00f3stico."},"content":{"rendered":"<p>Scand J Urol. 2018 Nov 1:1-7. doi: 10.1080\/21681805.2018.1505945. [Epub ahead of print]<\/p>\n<h1><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30382795\">Sclerosis as a predictive factor for failure after bulbar urethroplasty: a prospective single-centre study.<\/a><\/h1>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ekerhult%20TO%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30382795\">Ekerhult TO<\/a><sup>1<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Lindqvist%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30382795\">Lindqvist K<\/a><sup>1<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Grenabo%20L%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30382795\">Grenabo L<\/a><sup>1<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=K%C3%A5bj%C3%B6rn%20Gustafsson%20C%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30382795\">K\u00e5bj\u00f6rn Gustafsson C<\/a><sup>2<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Peeker%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30382795\">Peeker R<\/a><sup>1<\/sup>.<\/p>\n<p>Author information:<br \/>\n1. a Department of Urology , Institute of Clinical Sciences at Sahlgrenska Academy, Sahlgrenska University Hospital , Gothenburg , Sweden.<br \/>\n2. b Department of Pathology , Institute of Clinical Sciences at Sahlgrenska Academy, Sahlgrenska University Hospital , Gothenburg , Sweden.<\/p>\n<h3>Abstract<\/h3>\n<h4>OBJECTIVE:<\/h4>\n<p>The aim of this study was to assess whether sclerosis in histology following bulbar urethroplasty is a predictive factor for failure of surgery.<\/p>\n<h4>MATERIALS AND METHODS:<\/h4>\n<p>Resected stricture specimens from 45 patients undergoing open urethroplasty with excision and anastomosis were collected prospectively during 2011-2014. Histopathological characteristics, including fibrosis (grade I-III), inflammation and sclerosis, were evaluated using different routine staining. These specimens were compared to normal urethral resection specimens from patients undergoing sex-correction surgery. The uropathologist who conducted the analyses was blinded to the study design.<\/p>\n<h4>RESULTS:<\/h4>\n<p>The outcomes of the histological classifications were as follows: 19 patients had grade I fibrosis, of whom three had failures; 13 patients had grade II fibrosis, without any failures; and the most severe fibrosis, grade III, including sclerosis, was found in 13 patients (11 with sclerosis), with failure in eight. Sclerosis was a significant risk factor for restricture when comparing patients with sclerosis and those without sclerosis, and likewise when adjusting for age, inflammation and stricture length.<\/p>\n<h4>CONCLUSION:<\/h4>\n<p>Histological findings of sclerosis in the resected urethral stricture specimen indicate a significantly higher risk for restricture after urethroplasty surgery.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scand J Urol. 2018 Nov 1:1-7. doi: 10.1080\/21681805.2018.1505945. [Epub ahead of print] Sclerosis as a predictive factor for failure after bulbar urethroplasty: a prospective single-centre study. Ekerhult TO1,\u00a0Lindqvist K1,\u00a0Grenabo L1,\u00a0K\u00e5bj\u00f6rn Gustafsson C2,\u00a0Peeker R1. Author information: 1. a Department of Urology &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"more-link\" href=\"https:\/\/cru.aeu.es\/?p=741\"> <span class=\"screen-reader-text\">Esclerosis en la muestra histol\u00f3gica tras uretroplastia: pron\u00f3stico.<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-741","post","type-post","status-publish","format-standard","hentry","category-adulto-uretra"],"_links":{"self":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=741"}],"version-history":[{"count":1,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/741\/revisions"}],"predecessor-version":[{"id":742,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/741\/revisions\/742"}],"wp:attachment":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}