{"id":632,"date":"2017-11-18T07:28:34","date_gmt":"2017-11-18T07:28:34","guid":{"rendered":"http:\/\/cru.aeu.es\/?p=632"},"modified":"2017-11-18T07:28:41","modified_gmt":"2017-11-18T07:28:41","slug":"uretrotomia-interna-y-mitomicina-c","status":"publish","type":"post","link":"https:\/\/cru.aeu.es\/?p=632","title":{"rendered":"Uretrotom\u00eda interna y mitomicina C."},"content":{"rendered":"
Urology.<\/a><\/span>\u00a02017 Jul 20. pii: S0090-4295(17)30755-0. doi: 10.1016\/j.urology.2017.07.017. [Epub ahead of print]<\/div>\n

Internal<\/span>\u00a0Urethrotomy<\/span>\u00a0With Intralesional Mitomycin C: An Effective Option for Endoscopic Management of Recurrent Bulbar and Bulbomembranous Urethral Strictures.<\/h2>\n
Farrell<\/span>\u00a0MR<\/a>1<\/sup>,\u00a0Lawrenz CW<\/a>2<\/sup>,\u00a0Levine LA<\/a>2<\/sup>.<\/div>\n
<\/div>\n
\n

Abstract<\/h3>\n
\n

OBJECTIVE:<\/h4>\n

To describe our experience with direct visual\u00a0internal<\/span>\u00a0urethrotomy<\/span>\u00a0(DVIU) and mitomycin C (MMC) for recurrent bulbar and bulbomembranous urethral strictures of radiation and non-radiation-induced etiologies.<\/p>\n

METHODS:<\/h4>\n

We reviewed our database of consecutive patients presenting to our tertiary care institution with recurrent bulbar and bulbomembranous urethral strictures who underwent DVIU with MMC from 2011 to 2016. Patients were stratified by radiation-induced strictures (RIS) vs non-RIS. Cold-knife incisions were made at 12-, 3-, and 9-o’clock positions followed by intralesional injection of 10\u2009mL MMC (0.4\u2009mg\/mL) in 0.2-0.4\u2009mL aliquots and 1 month of postoperative daily clean intermittent catheterization (CIC).<\/p>\n

RESULTS:<\/h4>\n

All 44 patients (RIS n\u2009=\u200918, non-RIS n\u2009=\u200926) failed prior endoscopic management or urethroplasty. Median stricture length was 2.0\u2009cm (interquartile range [IQR] 1.0-2.5). Over a median follow-up of 25.8 months (IQR 12.9-47.2), 75.0% of patients (33\/44) required no additional surgical intervention (RIS 12\/18, 66.7%; non-RIS 21\/26, 80.8%). Median time to stricture recurrence among those who recurred was 10.7 months (IQR 3.9-17.6; RIS 9.4 months, IQR 3.5-17.6; non-RIS 11.2 months, IQR 8.0-25.6). Four patients (RIS n\u2009=\u20092, non-RIS n\u2009=\u20092) elected to undergo urethroplasty for recurrence. A second DVIU with MMC was performed in the remaining recurrences (n\u2009=\u20097) with no further surgical intervention required in 37 of 40 of patients (92.5%) overall (RIS 14\/16, 87.5%; non-RIS 23\/24, 95.8%). No long-term complications were attributable to MMC.<\/p>\n

CONCLUSION:<\/h4>\n

DVIU with MMC and short-term CIC for recurrent, short, bulbar and bulbomembranous urethral strictures is a safe endoscopic modality with promising early results. This approach may be useful for patients who are suboptimal candidates for open reconstruction.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Urology.\u00a02017 Jul 20. pii: S0090-4295(17)30755-0. doi: 10.1016\/j.urology.2017.07.017. [Epub ahead of print] Internal\u00a0Urethrotomy\u00a0With Intralesional Mitomycin C: An Effective Option for Endoscopic Management of Recurrent Bulbar and Bulbomembranous Urethral Strictures. Farrell\u00a0MR1,\u00a0Lawrenz CW2,\u00a0Levine LA2. Abstract OBJECTIVE: To describe our experience with direct visual\u00a0internal\u00a0urethrotomy\u00a0(DVIU) …<\/p>\n

Uretrotom\u00eda interna y mitomicina C.<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-632","post","type-post","status-publish","format-standard","hentry","category-adulto-uretra"],"_links":{"self":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=632"}],"version-history":[{"count":2,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/632\/revisions"}],"predecessor-version":[{"id":634,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/632\/revisions\/634"}],"wp:attachment":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}