{"id":430,"date":"2017-08-24T10:19:27","date_gmt":"2017-08-24T10:19:27","guid":{"rendered":"http:\/\/cru.aeu.es\/?p=430"},"modified":"2017-08-24T10:19:27","modified_gmt":"2017-08-24T10:19:27","slug":"ingenieria-tisular-de-mucosa-bucal-en-uretra","status":"publish","type":"post","link":"https:\/\/cru.aeu.es\/?p=430","title":{"rendered":"INGENIERIA TISULAR DE MUCOSA BUCAL EN URETRA"},"content":{"rendered":"<p>EBioMedicine. 2017 Aug 16. pii: S2352-3964(17)30331-6. doi: 10.1016\/j.ebiom.2017.08.014. [Epub ahead of print]<\/p>\n<p><strong>Results of Use of Tissue-Engineered Autologous Oral Mucosa Graft for Urethral Reconstruction: A Multicenter, Prospective, Observational Trial.<\/strong><\/p>\n<p>Ram-Liebig G1, Barbagli G2, Heidenreich A3, Fahlenkamp D4, Romano G5, Rebmann U6, Standhaft D6, van Ahlen H7, Schakaki S7, Balsmeyer U4, Spiegeler ME8, Knispel H8.<br \/>\nAuthor information<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>BACKGROUND:<br \/>\nHarvest of oral mucosa for urethroplasty due to urethral stricture is associated with donor-site-morbidity. We assessed functionality and safety of an authorized tissue-engineered oral mucosa graft (TEOMG) under routine practice in stricture recurrences of any etiology, location, length and severity (real-world data).<\/p>\n<p>METHODS:<br \/>\n99 patients from eight centers with heterogenous urethroplasty experience levels were included in this prospective, non-interventional observational study. Primary and secondary outcomes were success rate (SR) and safety at 12 and 24months.<\/p>\n<p>FINDINGS:<br \/>\nAll but one patient had \u22651, 77.1% (64 of 83)\u22652 and 31.3% (26 of 83)\u22654 previous surgical treatments. Pre- and postoperative mean\u00b1SD peak flow rate (Qmax) were 8.3\u00b14.7mL\/s (n=57) and 25.4\u00b114.7mL\/s (n=51). SR was 67.3% (95% CI 57.6-77.0) at 12 and 58.2% (95% CI 47.7-68.7) at 24months (conservative Kaplan Meier assessment). SR ranged between 85.7% and 0% in case of high and low surgical experience. Simple proportions of 12-month and 24-month SR for evaluable patients in all centers were 70.8% (46 of 65) and 76.9% (30 of 39). Except for one patient, no oral adverse event was reported.<\/p>\n<p>INTERPRETATIONS:<br \/>\nTEOMG is safe and efficient in urethroplasty.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EBioMedicine. 2017 Aug 16. pii: S2352-3964(17)30331-6. doi: 10.1016\/j.ebiom.2017.08.014. [Epub ahead of print] Results of Use of Tissue-Engineered Autologous Oral Mucosa Graft for Urethral Reconstruction: A Multicenter, Prospective, Observational Trial. Ram-Liebig G1, Barbagli G2, Heidenreich A3, Fahlenkamp D4, Romano G5, Rebmann &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"more-link\" href=\"https:\/\/cru.aeu.es\/?p=430\"> <span class=\"screen-reader-text\">INGENIERIA TISULAR DE MUCOSA BUCAL EN URETRA<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-430","post","type-post","status-publish","format-standard","hentry","category-adulto-uretra","category-bibliografiainteres"],"_links":{"self":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=430"}],"version-history":[{"count":1,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/430\/revisions"}],"predecessor-version":[{"id":431,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/430\/revisions\/431"}],"wp:attachment":[{"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cru.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}